BAP1 protein or BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase) is a de-ubiquitination enzyme encoded by BAP1 gene located on human chromosome 3. BAP1 (BRCA1-associated protein 1) binds to the N-terminal domain of BRCA1 and is a tumor suppressor gene.
BAP1 is involved in suppressing cell growth mediated by BRCA1.
BAP1 gene is involved in ocular cancers (uveal melanoma) and pleural cancers (mesothelioma). This work by Marc-Henri Stern (Institut Curie / Inserm U830) with Pr Dominique Stoppa-Lyonnet (Institut Curie / Service de Génétique) is published in American Journal of Human Genetics on June 6, 2013.
BAP1 function :
- Complex gene, tumor suppressor
- Enzymatic role: deubiquitinylase
- Role in DNA repair
- Member of “polycomb” group proteins that regulate cell proliferation and differentiation
BAP1 germline mutations lead to different types of tumors:
- Atypical melanocytic skin tumors
- Uveal melanoma - Cutaneous melanoma
- Mesothelioma (pleural and abdominal)
- Clear cell renal cancer
- Meningiomas in the cavity
| Format | Conditioning | Reference | Supplier | Certification | Dilution |
|---|---|---|---|---|---|
| Concentrated | 0,5 ml | 10149.05 |  |
RUO | 1/100 - 1/200 |
| Concentrated | 1 ml | 10149.10 | |
RUO | 1/100 - 1/200 |
| Ready to use | 5 ml | 10149.50 | |
RUO | - |