SATB2 (Special AT-sequence rich-Binding Protein 2) is a new very specific marker for colorectal cancer (CRC). This protein is selectively expressed in glandular cells of the lower gastrointestinal tract and its expression is conserved in a large majority of primary and metastatic CRCs.
SATB2 has been shown to provide 93% specificity and 100% sensitivity for colorectal carcinomas in combination with CK7 and CK20. SATB2, in combination with CK20 would identify more than 95% of all CRCs, including poorly differentiated colorectal carcinomas.