| Carcinomas Group 1 | ||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
CARCINOMAS |
CK Cocktail | CK7 | CK20 | CK, LMW | CK, HMW | CK5 | p63 | Vimentin | TTF-1 | Thyro globulin |
GCDFP-15 | ER/PR | CEA (poly) |
CDX-2 | Villin | Hep Par1 |
RCC | CD10 | Beta Catenin |
A-1 Antitrypsin |
| Hepatocellular Carcinoma |
– |
– |
– |
– |
– |
– |
– |
– |
+ |
– |
– |
– |
+ |
– |
– |
+ |
– |
+ |
– |
+/- |
| Renal Cell Carcinoma |
+ |
– |
– |
+ |
– |
– |
– |
+ |
– |
– |
– |
– |
– |
– |
– |
– |
+ |
+ |
– |
+ |
| Bladder Adenocarcinoma | + | + | +/- | + | + | – | – | – | – | – | – | – | + | + | – | – | + | – | ||
| Salivary Gland Carcinoma | + | + | – | + | + | + | + | – | – | – | – | + | – | – | – | – | – | – | ||
| Thyroid Carcinoma | + | + | – | + | – | – | + | + | + | – | – | – | – | – | – | – | – | – | ||
| Breast Carcinoma | + | + | – | + | + | – | – | – | – | + | + | +/- | – | – | – | – | – | + | – | – |
| Lung Adenocarcinoma | + | + | – | + | + | – | – | – | + | – | – | – | + | – | – | – | – | – | – | |
| Colorectal Adenocarcinoma | + | – | + | + | – | – | – | – | – | – | – | – | + | + | + | – | – | + | + | – |
| Prostatic Adenocarcinoma | + | – | – | + | – | – | – | – | – | – | – | – | – | – | – | – | – | + | – | – |
| Transitional Cell Carcinoma | + | + | + | + | + | + | + | – | – | – | – | – | – | – | – | – | – | + | – | – |
| Ovarian Carcinoma, Non Mucinous | + | + | – | + | + | + | – | – | – | – | – | + | – | – | – | – | – | – | – | – |
| Cervical Carcinoma | + | + | – | – | – | – | – | – | – | – | – | + | – | – | – | – | – | – | ||
| Sweat Gland Carcinoma | + | + | – | + | + | – | – | – | – | + | – | – | – | – | – | – | ||||
| Pancreatic Carcinoma | + | + | – | + | +/- | – | – | – | – | – | – | – | + | – | – | – | – | +/- | – | – |
| Gastric Carcinoma | + | + | – | – | – | – | – | – | – | – | + | + | + | – | – | – | – | |||
| Squamous Cell Carcinoma | + | – | – | + | + | + | + | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Endometrial Adenocarcinoma | + | + | – | + | + | – | – | – | + | – | – | – | – | – | + | – | ||||
| Carcinomas Group 2 | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| CARCINOMAS | CK7 | CK20 | CDX-2 | Villin | TTF-1 | Napsin A | PSA/PSAP | Caveolin-1 | Mammaglobin | GCDFP-15 | |
| Breast Carcinoma | + | – | – | – | – | – | – | + | + | + | |
| Lung Adenocarcinoma | + | – | – | – | + | + | – | – | – | – | |
| Transitional Cell (Bladder) Carcinoma | + | + | – | – | – | – | – | – | – | – | |
| Colorectal Adenocarcinoma | – | + | + | + | – | – | – | + | – | – | |
| Prostatic Adenocarcinoma | – | – | – | – | – | – | + | +/- | – | – | |
| Squamous vs Transitional Carcinomas | ||||||||
|---|---|---|---|---|---|---|---|---|
| CARCINOMAS | CK,34bE12 | p63 | CK5 | Thrombomodulin | CK7 | CK20 | Uroplakin III | COX-2 |
| Squamous Carcinoma | + | + | + | + | – | – | – | – |
| Transitional Cell Carcinoma | + | + | -/+ | + | + | + | + | + |
| Small Cell vs Merkel Cell Carcinomas | ||||||||
|---|---|---|---|---|---|---|---|---|
| CARCINOMAS | TTF-1 | CEA | CK20 | Chromogranin A | E-Cadherin (nuclear) | Neurofilament | CD117 | Synaptophysin |
| Merkel Cell Carcinoma | – | – | + | + | + | + | + | + |
| Small Cell Carcinoma | + | – | – | – | – | – | +/- | + |
| Cutaneous Neoplasms | |||||||
|---|---|---|---|---|---|---|---|
| CARCINOMAS | CD10 | Androgen Receptor | CK20 | CD34 | Ber-EP4 | bcl-2 | CK19 |
| Basal Cell Carcinoma | + | + | – | – | + | + | + |
| Trichoepithelioma | – | – | + | + | + | + | + |
| Merkel Cell Carcinoma | – | – | + | – | + | + | + |
| Microcystic Adnexal Carcinoma | +/- | – | – | – | -/+ | + | |
| Sebaceous Carcinoma | +/- | + | – | – | + | +/- | – |
| Sebaceous Adenoma | – | + | – | – | + | + | – |
| Carcinomas: Differential Diagnosis | ||||||||
|---|---|---|---|---|---|---|---|---|
| CARCINOMAS | Androgen Receptor | BCA-225 | GDDFP-15 | ER/PR | Mammaglobin | Ny-BR-1 | PSA/PSAP | CD44 |
| Salivary Duct Carcinoma | + | + | + | – | – | – | – | – |
| Breast Carcinoma | +(aprocrine) | + | + | +/- | + | + | – | + |
| Prostate Carcinoma (nuclear) | + | – | – | – | – | – | + | + |
| Prostate Lesions | ||||||||
|---|---|---|---|---|---|---|---|---|
| CARCINOMAS | PSA/PSAP | P504s | CK, 34bE12 | p63 | CK7 | Thrombomodulin | Uroplakin III | PAX-2 |
| Prostate Carcinoma | + | + | – | – | – | – | – | – |
| Urothelial Carcinoma | – | – | + | + | + | + | + | – |
| Nephrogenic Adenoma | – | + | +/- | – | + | – | – | + |
| Lung Carcinomas | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| CARCINOMAS | CD56 | Chromogranin A | Synaptophysin | CK7 | Napsin A | p63 | TTF-1 | BG8 | GLUT-1 |
| Small Cell Carcinoma | + | -/+ | +/- | – | – | – | + | + | – |
| Adenocarcinoma | – | – | – | + | + | – | + | + | +/- |
| Squamous Cell Carcinoma | – | – | – | – | – | + | – | + | + |
| Large Cell Neuroendocrine Carcinoma | + | + | + | +/- | – | – | +/- | ||
| Colon vs Ovarian Carcinoma | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| CARCINOMAS | CK7 | CK20 | CEA | CDX-2 | Villin | CA19-9 | Ep-CAM | WT1 | CA-125 | CK5/6 | PAX-8 |
| Ovarian Carcinoma, Serous | + | – | + | – | + | + | + | + | + | – | + |
| Ovarian Carcinoma, Mucinous | +/- | +/- | – | + | + | + | + | – | – | – | |
| Ovarian Endometrioid Carcinoma | + | – | – | – | +/- | + | -/+ | + | – | + | |
| Colon Carcinoma | – | + | + | + | + | + | + | – | – | – | – |
| Mucin Expression in Neoplasms | ||||
|---|---|---|---|---|
| CARCINOMAS | MUC1 | MUC2 | MUC5AC | MUC6 |
| Pancreatic Adenocarcinoma | + | – | + | – |
| Lung Carcinoma, Signet Ring | + | – | + | |
| Ovarian Adenocarcinoma | + | – | + | |
| Gastric Carcinoma | – | -/+ | + | -/+ |
| Cervical Adenocarcinoma | + | – | + | – |
| Esophageal Carcinoma | + | – | + | |
| Paget’s Extramammary | + | -/+ | + | – |
| Cholangiocarcinoma | + | – | +/- | – |
| Salivary Duct Adenocarcinoma | – | + | – | + |
| Colon Carcinoma, Signet Ring | – | + | – | – |
| Prostate Carcinoma | – | +/- | – | – |
| Pancreatic Intraductal Papillary Carcinoma | – | + | + | + |
| HCC | – | – | – | – |
| Adrenocortical Carcinoma | – | – | – | – |
| Breast Carcinoma | + | – | – | – |
| Lung Carcinoma | + | – | – | |
| Kidney Carcinoma | + | – | – | |
| Bladder Carcinoma | + | – | – | |
| Endometrial Carcinoma | + | – | – | – |
| Ovarian Carcinoma, Mucinous | + | – | + | |
| Renal Cell Carcinoma | + | – | – | |
| Urothelial Carcinoma | + | – | – | |
| Appendiceal Adenocarcinoma | – | + | + | – |
| Barrett’s Esophagus | + | + | + | – |
| Pancreatic Mucinous Cystic | – | – | + | – |
| Breast Colloid Carcinoma | + | + | – | + |
| Mucin Expression in Organs | |||||
|---|---|---|---|---|---|
| CARCINOMAS | MUC1 | MUC2 | MUC4 | MUC5AC | MUC6 |
| Stomach | + | – | + | + | + |
| Small Intestine | – | + | – | – | + |
| Colon | – | + | – | – | |
| Pancreas | + | – | – | – | + |
| Ampullary Carcinoma (Enteric vs Ductal) | |||
|---|---|---|---|
| CARCINOMAS | CK17 | Hep-Par1 | CDX-2 |
| Enteric | – | + | – |
| Ductal | + | – | -/+ |
| Colon vs Prostate Adenocarcinoma | ||||||
|---|---|---|---|---|---|---|
| CARCINOMAS | CDX-2 | CK20 | CEA | CA19-9 | PSA | P504s |
| Colon Adenocarcinoma | + | + | + | + | – | – |
| Prostate Adenocarcinoma | – | – | – | – | + | + |